Google Tech TalksOctober 30, 2008ABSTRACTIn 18 months full human genome sequences will be available under $100 - and in minutes. The $5,000 full human genome was announced to come in 9 months. Is "Big IT" ready for the avalanche of data, to be obtained and processed e.g. while the patient is still on the operating table, to be diagnosed, and how the genomics glitch, that caused a benign or malign tumor, could be compensated for?Algorithmic approaches are needed to better understand genome regulation, even for the simple reason to deploy most effective data retrieval, data storage and computational means, via both parallel hardware and software, but more importantly for opening entirely new perspectives.In the 100+ year old Genomics, for over half a Century had us to resign to the fatalistic gloom that we are stuck with any glitches in our inherited genome. Is it true that genomic glitches doom one to "incurable" hereditary diseases?No longer. Genomics now considers the DNA-RNA-Protein chain not as a thermodynamically closed system, where entropy increases, but as an open system that can be interfered with. There is theoretically sound hope that you are not stuck with your genomic glitches.After half a Century of sticking to two mistaken axioms of Genomics, the paradigm of recursive genome function must quickly make up for lost time for those (potentially) inflicted with formerly "incurable" diseases. "The Genome baby is left on the doorsteps of Information Technology".Doctors sent those inflicted with fleece for "debugging". Debugging genome information (by Genome Computers) would be much harder without understanding the algorithms that our natural genome computing operates with.Speaker: Dr. Andras PellioniszPh.D. in BiologyPh.D. in Computer EngineeringDirector of Genome Informatics, Mitrionics, Inc., Los Gatos, CaliforniaEuropean Union visiting Professor for Hungary (for "European Inaugural of IPGS")Founder of International PostGenetics Society (IPGS,PostModern era of Genetics "beyond Genes")Founder of FractoSoft (Software for PostGenetics, Silicon Valley, with Central European outsourcing)Founder of Helixometry (IP portfolio holding, Silicon Valley)Inventor and Founder of FractoGene (Fractal approach to DNA)Chief Software Architect and Chief Intelligence Officer of several Silicon Valley Internet Companies in the dot.com boomFounder of International Neural Networks Society (INNS)Founding Editor of Neural Networks (publication organ of INNS)Section Editor for Neural Networks of The Cerebellum (Springer, New York&Heidelberg)Professor of Physiology and Biophysics, New York University Medical CenterVisiting Professor of Marburg University, Germany (Humboldt Prize for Senior Distinguished Amercian Scientists)Visiting Professor of UMR/CNRS, College de France, ParisSenior Research Council Associate of the National Academy of Science, USA, to NASAPostDoctoral Fellow, University of IowaPostDoctoral Fellow, Stanford UniversityTenured Senior Research Fellow of the Hungarian Academy of Sciences
With the affordable full human DNA sequencing already here (Complete Genomics shown their first full human DNA sequence for $5,000 in the February 5th meeting in Marco Island, FL - and Pacific Biosciences published a "proof of concept" paper in Science for full DNA sequencing in the range of $100 in little over a year from now, we are all heading towards a "Genome Based Economy". The Churchill Club held a Panel on January 22, 2009 with the title "Personal Genome Computing" - search it in YouTube
Pellionisz(February 10, 2009 at 8:26 am)
Thomas Kuhn, in his bestseller book "The Structure of Scientific Revolutions" (1969) said that in a paradigm-shift the old and new definitions are mutually incompatible. Wouter van Ooijen, a young computer scientist, is apparently unaware of the fact that ENCODE (June 14, 2007) called for a "re-thinking of old beliefs" of 100-year old Genetics; including the very definition of what a "Gene" might be. One might recommend viewing a Panel (YouTube "pellionisz") struggling with the same challenge.
Pellionisz(January 18, 2009 at 8:09 am)
My PR warns against anonymous "shitck" name-callers. Great that you second my statement: DNA is an OPEN SYSTEM where genome entropy is not inevitable to escalate. So let's give hope, not a gloomy mindset that we are stuck with genomic glitches! Interdisciplinary scientists note I focused on DNA - not cells. With energy pumped into it, entropy increases - unless DNA is open to changes by epigenomic interference. Molecular biologists will agree that methylation is #1 mechanism in the limelight.
darked89(January 17, 2009 at 12:21 pm)
@33'01''Slide reads:"""As long as DNA>RNA>PROTEIN was a closed system The Second Law of Thermodynamics applied - an increase of enthropy was inevitable"""FYO: nobody who is somebody ever said that a cell, DNA, replication, transcription or translation is a closed system, much less so Watson, Crick or Ohno. You need energy (ATP)to run any of these. Methylation or not it is an OPEN SYSTEM.
darked89(January 12, 2009 at 9:18 am)
Waste of time. This guy shitck is to dazzle biologist with comp-math-phis terms (fractal, recurency, FPGA) and comp guy with bio terms (Purkinje cells etc.). It does not work fr a bioinformatician.I quited soon after statement that without DNA methylation we would have problem with thermodynamics of DNA. Wow, simply wow! So Second law is so specific? Using energy DNA repair is not good enough?Bombastic names ("circle of life" anyone?), prosecution complex + penchant for kicking corpses.
sntk1(January 5, 2009 at 6:25 pm)
This is a piece of blithering buffoonery from someone who doesn't begin to understand Pellionisz, much less the import of his ideas.
WouterVanOoijen(December 14, 2008 at 7:23 pm)
This sounds good, but once you actually analyse what he says it is often total nonsense. A mix of words from various sciences, used with total disregard for their definitions.
DrugFreedom(November 3, 2008 at 4:14 pm)
This is an interesting video.It looks like Terrence McKenna had some promising ideas about genetic evolution after all...
davidwizard2006(November 1, 2008 at 8:10 am)
sarah ann boswell
madashelldude(November 1, 2008 at 1:59 am)
Wow, 18 months?! Finally we'll know the origins and migration paths of all nations, this could be explosive in Eastern Europe. Hungarians tried to find their ancestral home for centuries. This will become political very fast.
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